Browsing by Author "Safe, Stephen H."
Now showing items 1-20 of 50
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Elmore, Sarah Elizabeth (2016-05-06)Aflatoxins (AFs) are toxic metabolites produced by Aspergillus flavus and A. parasiticus. Fumonisins (FBs) are also toxic products of fungi, specifically Fusarium verticilloides and F. proliferatum. Both toxins commonly ...
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Sericano, Jose Luis (Texas A&M University. Libraries, 1993)This study was designed to examine the uptake and depuration of trace organic contaminants, e.g. poly nuclear aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), including planar congeners, and butyltin species, ...
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Rowlands, Justin Craig (Texas A&M University. Libraries, 1993)2,3,7,8 -Tetrachlorodibenzo-p-dioxin (TCDD) is a broad spectrum antiestrogen which works through the aryl hydrocarbon (Ah) receptor. The estrogen receptor (ER) positive hum an ovarian carcinoma cell lines PE01, PE04 and ...
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Dickerson, Richard Lee (Texas A&M University. Libraries, 1992)Polychlorinated dibenzo-p-dioxins and dibenzofurans are environmental contaminants which elicit a number of toxic and biochemical effects including immunotoxicity, hepatic microsomal monooxygenase induction and enodcrine ...
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Bowes, Russell C. (Texas A&M University. Libraries, 1994)The present studies were conducted to assess cell-specific cytotoxic responses of the kidney to selected aromatic hydrocarbons (AHs) using in vitro culture systems of glomerular mesangial (GMCs) and cortical tubular ...
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Naufal, Ziad Sami (2009-05-15)Maternal exposure to genotoxic chemicals may produce a variety of adverse birth outcomes. Depending on the dose and duration of exposure, adverse birth outcomes can range from premature or low-birth weight, to congenital ...
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Johnson, Natalie Malek (2011-10-21)The need to assess human exposures to foodborne and environmental carcinogens, particularly in populations at high risk for cancer and disease, has led to the development of chemical-specific biomarkers. Sensitive biomarkers ...
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Safe, Stephen H. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2013-03-05)The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 ?m. In addition, the ...
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Scott, Maya Millicent (Texas A&M University, 2006-08-16)Tissue slices can be made from organs, such as liver, kidney, brain, and heart, and from various species including humans, dogs, non-human primates, rats and mice. It has been demonstrated that human and rat liver slices ...
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Wiles, Melinda Christine (Texas A&M University, 2004-11-15)Substantial environmental contamination has occurred from coal tar creosote and pentachlorophenol (C5P) in wood preserving solutions. The present studies focused on the characterization and remediation of these contaminants. ...
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Safe, Stephen H. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2010-05-04)Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which ...
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Lum, Karin Tien (Texas A&M University, 2004-09-30)Directed evolution studies were done with PTE for the enhancement of hydrolysis of both sarin and soman analogs. Particular attention was focused on the toxic SpRc and SpSc isomers of the soman analog, and the Sp isomer ...
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Kim, KyoungHyun (Texas A&M University, 2005-11-01)Estrogen Receptor ? (ER?)/Sp1 activation of GC-rich gene promoters in breast cancer cells is dependent, in part, on the activation function 1 (AF1) of ER?. This study investigates contributions of the DNA binding domain ...
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Krishnan, Venkatesh (Texas A&M University. Libraries, 1994)TCDD is a broad spectrum antiestrogen and mediates its antiestrogenic effects through the aryl hydrocarbon receptor (AhR). 176-estradiol (E2) induces the secretion of procathepsin D, a 52-kDa protein in MCF-7 human breast ...
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Hanson, Curtiss Dwight (Texas A&M University. Libraries, 1989)Fourier transform ion cyclotron resonance (FT-ICR) is the observation of an image current induced by a well defined ion packet, consequently the high resolution and high sensitivity arise from the ability to produce coherent ...
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Safe, Stephen H. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2000-10-24)Methods and pharmaceutical combinations for inhibiting estrogen-dependent tumors via the co-administration of antiestrogen triphenylethylenes, including tamoxifen, and alkyl PCDFs.
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Pangilinan, Norma Cabanos (Texas A&M University. Libraries, 1990)The metabolism of xanthotoxin, a naturally-occurring furanocoumarin photosensitizer, was studied in laying hens and lactating goats treated with a single oral dose equivalent to 10 mg xanthotoxin/kg of body weight. Within ...
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Abdel Rahim, Ma'en Ahmad (Texas A&M University, 2004-09-30)Sequence-specific small interfering RNA (siRNA) duplexes can be used for gene silencing in mammalian cells and as mechanistic probes for determining gene function. Transfection of siRNA for specificity protein 1 (Sp1) in ...
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Safe, Stephen H.; Chintharlapalli, Sudhakar; Mcalees, Alan; Mccrindle, Robert (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2013-03-05)The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr ...
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Haake, JoEllyn Marie (Texas A&M University. Libraries, 1987)The effects of various halogenated hydrocarbon pollutants on hepatic microsomal drug and steroid metabolizing enzymes were determined in neonatal, immature and adult Long Evans rats. The teratogenic and/or fetotoxic effects ...